Effects of Crude Extracts of Morinda citrifolia (Noni) Leaves to Blood Glucose Level of Alloxan-Induced Male Mice

This study was conducted to determine the effect of Morinda citrifolia on blood glucose level in mice which were induced with alloxan. The experimental design was used by the researchers. Nine (9) mice were properly chosen through purposive sampling based on the set of criteria. They were assigned into three (3) groups, labeled as Negative (3), Experimental (3) and Positive (3) Control groups. After 8-hour fasting, hyperglycemia was induced by single intra-peritoneal injection of alloxan monohydrate (150mg/kg/ml). Two days after induction of alloxan, mice with plasma glucose levels of >130mg/dl were included in the study. Treatments were started 48 hours after induction of alloxan. ANOVA was used to validate the results of this study and reinforced by the use of Tukey’s Test. The study yielded the following results:  Negative control group (T0) did not receive any treatment after induction of alloxan and continuously increased blood glucose level. Experimental control group (T1) proved that blood glucose level decreased with an average of 11% after an administration of Noni extracts whereas in Positive control group (T2) showed that the blood glucose level decreased with an average of 40% after administration of Metformin Hydrochloride. Overall, the Noni extract showed a minimal hypoglycemic activity.

 

Keywords: Alloxan monohydrate, Morinda citrifolia, Noni, Metformin Hydrochloride, Blood Glucose Level