Mangosteen (Garcinia mangostana) Linn. Pericarp on Irradiated Webster White Mice (Mus musculus) Linn.

Radiation exposure can cause damage to organ tissues if not observe. The researcher conducted the study on mangosteen (Garcinia mangostana L.) pericarp ethanolic extract which contains high antioxidant content, the xanthone. The study is about the effect of xanthone extract from the mangosteen fruit that may protect any pathological conditions caused by X-radiation. The xanthone extract was administered for two weeks on Webster white mice (Mus musculus) Linn. prior to irradiation and evaluation. Twenty-four mice were divided into four groups (control group, treatment with radiation exposure, no treatment with exposure, treatment with no exposure). A histopathological study was conducted to assess the protective activity of xanthones from the mangosteen extracts. Histopathological analysis found that the mice treated with xanthone extract and exposed to X-radiaton show no significant lesions in the mammary gland tissues of the white mice compared to the mice without treatment of mangosteen pericarp extract and exposed to x-radiation. The use of mangosteen pericarp extract showed indications of minimized presence of any pathological condition caused by radiation exposure, assessing the administration of supplement and placement and ecological aspect that may affect the health and behavioral status of the mice.

 

Keywords: Radiation, antioxidant, mangosteen, mammary gland, Webster white mice