Effect of Crude Extract from Ixora coccinea (Santan) Flower in the Damaged Liver of the Albino Rabbit

The effect on the damaged liver of albino rabbit of Ixora coccinea (santan) flower crude extract was investigated in this study, using acetaminophen-induced liver damage in the albino rabbit. Maceration, filtration, and evaporation method was used to obtain the crude extract of santan flower. Nine (9) albino rabbits were used as test subjects. The test subjects were randomly selected to form three groups: the control group (not receiving any substance), the positive control group (receiving sliymarin), and the experimental group (receiving the santan flower crude extract). The three groups were each composed of three albino rabbit as replicates.Acetaminophen (diluted with sufficient amount of distilled water was able to significantly increase the level of liver enzyme alanine aminotransferase (ALT) of the albino rabbit subjects after it was administered as an agent for liver damage into the albino rabbit. Moreover, there were no significant decreases on the level of liver enzyme ALT when compared to silymarin.

Keywords:  Ixora coccinea (santan), acetaminophen, liver damage, and alanine aminotransferase (ALT), crude extract