The Effect of Crude Extract from Hibiscus rosasinensis Linn. (Gumamela) Calyx and Petal on Paracetamol Hepatotoxicity Induced Albino Rabbit

The study investigated the effect of crude extract from Gumamela calyx and petal on Paracetamol hepatotoxicity induced albino rabbit. This is to search a new substance that can treat hepatotoxicity. The Gumamela plant contains anthocyanin which is reported to have an antioxidant property used in treating hepatotoxicity. The test animals used in the study were albino rabbits. The blood of the Albino rabbits blood was examined employing the liver function test, specifically serum glutamic pyruvic transaminase to determine the effect of Gumamela crude extract in treating paracetamol induced hepatotoxicity. The albino rabbits were grouped into two, and induced with 2000 mg/kg of Paracetamol. After 24 hours, first group was treated with 500mg/kg body weight of crude extract and the second group was treated with Silymarin 50mg/kg body weight. Data were gathered and subjected to statistical analysis. It was revealed that the crude extract from Hibiscus rosasinensis Linn.(Gumamela) showed no significant difference using Silymarin as the reference standard. Thus, it can be concluded that the Silymarin and gumamela calyx and petal have the same effect.

Keywords:  Hibiscus rosasinensis Linn. (Gumamela), antioxidant, hepatotoxicity, liver function test, serum glutamic pyruvic transaminase level